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52-Week Top Losing U.S. stocks

Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.

52-Week Top Losing U.S. stocks

Market Overview

U.S. stocks are mixed today. The Dow Jones is ⁦-0.14%⁩, the S&P 500 is ⁦+0.63%⁩, and the Nasdaq Composite is ⁦+1.36%⁩. Across individual stocks, 2,273 are advancing while 2,844 are declining, suggesting a mixed market tone.

Dow Jones
51,452.02
Change
-71.04-0.14%
S&P 500
7,400.19
Change
+46.46+0.63%
Nasdaq Composite
24,646.821
Change
+331.824+1.36%
24H Gainers
2,273
24H Losers
2,844

52 Week Losers

#Stock52 Week Range
5101Relay Therapeutics, Inc.RLAY$18.45+6.62%2.04M$4.04B$5.95 - $21.270.00%
5102Absci CorporationABSI$10.20+8.09%3.01M$1.75B$2.24 - $12.540.00%
5103Butterfly Network, Inc.BFLY$6.39+5.35%2.32M$1.57B$1.90 - $10.210.00%
5104Bandwidth Inc.BAND$40.54+6.85%271.96K$1.23B$12.50 - $79.080.00%
5105Paysign, Inc.PAYS$14.65+1.89%474.51K$827.45M$3.08 - $16.150.00%
5106Micron Technology, Inc.MU$693.26+5.36%35.57M$784.37B$192.59 - $1,255.000.00%
5107American Well CorporationAMWL$12.00-0.91%61.14K$180.73M$3.71 - $15.160.00%
5108Vera Bradley, Inc.VRA$6.93-0.43%364.39K$198.81M$1.39 - $7.720.00%
5109Kelly Services Inc.KELYB$26.86+5.15%758$88.55M$8.38 - $125.000.01%
5110Tilly's Inc.TLYS$4.26+1.43%52.98K$99.13M$1.14 - $6.250.00%
5111Eton Pharmaceutcials, Inc.ETON$57.41+21.23%913.64K$1.64B$14.27 - $66.370.00%
5112SAIHEAT LimitedSAIH$21.21-4.48%4.20K$25.36M$5.90 - $33.000.00%
5113RF Acquisition Corp IIRFAI$32.12+7.07%2.80K$112.82M$8.94 - $73.000.00%
5114Rallybio CorporationRLYB$15.55-1.11%18.79K$83.75M$3.67 - $17.570.00%
5115Quhuo LimitedQH$2.77-2.98%2.20K$7.98M$0.07 - $12.810.00%
5116Able View Global Inc.ABLV$2.74+4.31%52.97K$67.18M$0.54 - $2.960.00%
5117Entravision CommunicationEVC$8.87+18.13%2.03M$735.22M$2.56 - $13.740.03%
5118Century Therapeutics, Inc.IPSC$1.68+10.60%1.58M$303.30M$0.43 - $3.040.00%
5119Ampco-Pittsburgh Corp.AP$6.04+1.34%53.28K$124.67M$1.75 - $12.810.00%
5120Revolution Medicines, Inc.RVMD$193.46+8.65%2.82M$41.47B$58.91 - $224.310.00%
5121GIBO Holdings LimitedGIBO$166.58+6.26%17.59K$250.03M$22.60 - $187.720.00%
5122MaxLinear, Inc.MXL$48.38+8.75%1.99M$4.40B$12.77 - $128.300.00%
5123Pulse Biosciences, Inc.PLSE$52.04-2.00%279.53K$3.68B$12.56 - $63.390.00%
5124Iovance Biotherapeutics, Inc.IOVA$8.15+5.62%8.14M$3.69B$2.08 - $15.370.00%
5125Nuvectis Pharma, Inc.NVCT$20.17+13.40%170.22K$658.40M$5.55 - $29.270.00%
5126Oruka Therapeutics, Inc.ORKA$102.51+5.28%649.99K$6.79B$25.23 - $115.520.00%
5127AN2 Therapeutics, Inc.ANTX$4.08+0.76%144.51K$153.78M$1.00 - $7.190.00%
5128Alpha Tau Medical Ltd.DRTS$13.85+4.02%229.72K$1.25B$3.43 - $15.790.00%
5129OmniAb, Inc.OABI$5.07+4.76%835.06K$740.10M$1.33 - $5.430.00%
5130Veradermics, IncorporatedMANE$139.39+8.25%323.43K$5.58B$32.00 - $146.570.00%
5131Twist Bioscience CorporationTWST$118.81-1.18%1.42M$7.45B$23.30 - $219.710.00%
5132Sandisk CorporationSNDK$826.55+2.02%14.53M$160.29B$183.00 - $2,354.390.00%
5133Q32 Bio Inc.QTTB$9.26+4.97%124.84K$275.67M$1.91 - $23.570.00%
5134PACS Group, Inc.PACS$49.94-0.70%362.44K$7.90B$10.31 - $51.680.01%
5135ImmunityBio, Inc.IBRX$8.54+6.43%5.91M$9.05B$1.95 - $12.430.00%
5136Anterix Inc.ATEX$76.10+10.23%106.54K$1.49B$17.58 - $113.000.00%
5137New Century Logistics (BVI) LimitedNCEW$17.27+5.82%25$55.28M$2.80 - $20.830.00%
5138Fossil Group, Inc.FOSL$7.88+2.00%988.98K$465.71M$1.70 - $8.060.00%
5139AXT Inc.AXTI$38.95+4.90%9.14M$2.55B$7.81 - $143.160.00%
514010x Genomics, Inc.TXG$57.62-0.43%3.13M$6.93B$12.80 - $102.810.00%
5141STAK Inc.STAK$2.97+64.25%25.27M$29.39M$0.29 - $12.000.00%
5142Spyre Therapeutics, Inc.SYRE$102.84+5.93%694.88K$10.48B$21.14 - $110.170.00%
5143Vince Holding Corp.VNCE$12.72+0.16%192.33K$164.64M$1.95 - $13.880.00%
5144Avita Medical, Inc.RCEL$16.62+5.87%813.42K$511.51M$3.22 - $17.820.00%
5145SELLAS Life Sciences Group, Inc.SLS$8.21+3.30%6.17M$1.66B$1.39 - $15.880.00%
5146CareDx, Inc.CDNA$77.85+2.79%751.03K$4.09B$14.58 - $90.870.00%
5147Climb Bio, Inc.CLYM$10.21+13.98%664.69K$586.19M$1.64 - $18.330.00%
5148Space Exploration Technologies Corp.SPCX$134.96+8.80%88.87M$1.92T$21.32 - $225.640.00%
5149Kodiak Sciences Inc.KOD$99.11+7.15%437.27K$6.23B$15.83 - $104.000.00%
5150Erasca, Inc.ERAS$13.97+4.82%2.08M$4.89B$2.10 - $24.280.00%

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Frequently Asked Questions (FAQ)

What are 52-week top losing U.S. stocks?
These are U.S. stocks that have recorded some of the largest price declines over the past 52 weeks.
How is the 52-week decline measured?
It compares the latest available stock price with its price around 52 weeks earlier and calculates the percentage change.
Which stock has fallen the most over 52 weeks?
Relay Therapeutics, Inc. (RLAY) currently shows a 52-week decline of 182.47% as of 2026-11-06 20:00 UTC.
Why track 52-week stock losers?
The ranking helps identify stocks facing prolonged price weakness and provides a starting point for further company and valuation research.
Is a 52-week loser automatically a value stock?
No. A lower stock price does not necessarily mean a company is undervalued, so valuation and fundamental data should be reviewed separately.
How is this different from Top Losers?
52-Week Losers measures longer-term performance, while Top Losers focuses on shorter-term market declines.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.